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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Schizophr Res. 2017 Feb 12;187:74–81. doi: 10.1016/j.schres.2017.02.001

Figure 3. Haloperidol, but not clozapine, increased 7DHC and 8DHC levels in the rat striatum and prefrontal cortex.

Figure 3

Chronic haloperidol treatment at 0.2 mg/kg/day, for 24 days, increased levels of 7DHC and 8DHC in the rat striatum, A, and prefrontal cortex, C. A trend toward increase was also observed at 0.05 mg/kg/day haloperidol, while chronic clozapine treatment had no effect. Patterns were similar if samples were normalized to protein (not shown), or to cholesterol levels. B, D, cholesterol levels (ng/μg protein) in striatum and prefrontal cortex, respectively. Gray boxes show non-parametric Anova data. ***p<0.0001 in post-hoc analysis using Dunnett’s comparison to control.