Table 2.
Reasons for and times of premature discontinuations (TTS, N = 62)
| Reason for discontinuation | N (%) | Time of discontinuation (after infusion number) |
|---|---|---|
| Adverse event | 4 (6.5) | |
| Infusion-related reactiona,b | 1 (1.6) | 1c |
| Recurrent neutropeniab | 1 (1.6) | 4 |
| Hodgkin’s diseased | 1 (1.6) | 5 |
| Gastrointestinal disorders and ascitesd | 1 (1.6) | 5 |
| Withdrawal of consent | 2 (3.2) | 7 and 8 |
| Late identification of an exclusion criterion | 1 (1.6) | 2 |
| Pregnancy | 1 (1.6) | 6 |
| Omission of the last study visit | 1 (1.6) | 15 |
TTS total treated set
aConsisting of a transient episode of dyspnoea, oropharyngeal pain, and chest pain
bDrug-related
cFive minutes after the start of the infusion
dNot drug-related