Table 1.
Issue | Jeremic et al. | CREST |
---|---|---|
Less favorable patients (PS2) | 0% | 10% |
Initial (pre-randomization) CHT | 3 cycles | 6 cycles |
TRT (dose/fx) | 54 Gy/36fx BID—Hyperfx |
30 Gy/10fx QD—Hypofx |
CHT-TRT | CHT followed by concurrent TRT-CHT | CHT followed by TRT (no concurrent part) |
PCI—TRT | PCI followed TRT-CHT | Concurrent in almost 90% pts |
CHT, chemotherapy; TRT, thoracic radiotherapy; fx, fraction; BID, hyperfractionation (2 fx a day); QD, conventional fractionation (1 fx a day); PCI, prophylactic cranial irradiation.