Table 1.

Patient and treatment characteristics.

Issue	Jeremic et al.	CREST
Less favorable patients (PS2)	0%	10%
Initial (pre-randomization) CHT	3 cycles	6 cycles
TRT (dose/fx)	54 Gy/36fx BID—Hyperfx	30 Gy/10fx QD—Hypofx
CHT-TRT	CHT followed by concurrent TRT-CHT	CHT followed by TRT (no concurrent part)
PCI—TRT	PCI followed TRT-CHT	Concurrent in almost 90% pts

CHT, chemotherapy; TRT, thoracic radiotherapy; fx, fraction; BID, hyperfractionation (2 fx a day); QD, conventional fractionation (1 fx a day); PCI, prophylactic cranial irradiation.