Table 2.

Outcomes.

Issue	Jeremic et al.	CREST	Comments
Importance of improved LC	Yes	Yes	Leads to improved OS
Tempo of achieving improvement of LC	Faster	Slower	Leads to a faster improvement of OS in Jeremic et al.
OTT	Shorter	Longer	Possible due to better patient characteristics in Jeremic et al.
Incidence of high-grade toxicity	5% (lung) 20% (esophagus)	1.2% (lung) 1.6% (esophagus)	Higher TRT doses and concurrent CHT in Jeremic et al.
Duration of CHT	Shorter	Longer	Shorter appropriate in favorable patients?

LC, local control; OS, overall survival; OTT, overall treatment time; TRT, thoracic radiotherapy; CHT, chemotherapy.