Table 3.
Univariate and multivariate analysis for PFS from auto HCT.
| Covariates | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Chrom 1 gain | 1.99 (0.99–4.00) | .05 | 2.03 (1.00–4.09) | .049 |
| Male gender | 1.64 (0.88–3.05) | .12 | – | |
| Isotype – IgG | Reference | .69 | – | |
| IgA | 0.75 (0.32–1.75) | |||
| Kappa LC | 1.32 (0.59–2.98) | |||
| Lambda LC | 0.76 (0.26–2.22) | |||
| ISS stage – I | Reference | .27 | Reference | .25 |
| II | 1.5 (0.74–3.04) | 1.53 (0.76–3.12) | ||
| III | 1.85 (0.84–4.04) | 1.86 (0.85–4.08) | ||
| Lytic lesions at dx | 0.9 (0.41–1.94) | .78 | – | |
| EMD at dx | 1.54 (0.83–2.85) | .17 | – | |
Auto HCT: autologous hematopoietic cell transplantation; dx: diagnosis; EMD: extramedullary disease; ISS: International Staging System; LC: light chain; PFS: progression-free survival. Bold value indicates significant p values.