FIGURE 2.

Seed based correlation analysis relating aerobic capacity to resting state functional connectivity. (A) At baseline, aerobic capacity (VO₂-peak) was primarily positively (blue) correlated with right medial temporal lobe connectivity to frontal, parietal, and occipital areas. Negative correlations between aerobic capacity and connectivity of the same seed were observed to thalamus and occipital regions. (B) Longitudinal gains in aerobic capacity predicted increased functional connectivity between the right medial temporal lobe and frontal and parietal regions. (C) Change in aerobic capacity is negatively associated with connectivity between left hippocampus and contralateral precentral gyrus. Green areas indicate seed regions; blue indicate positive associations to (change in) aerobic capacity; red indicates negative associations.