Table 3.
Relationships between functional connectivity and aerobic capacity at baseline and change over time.
| Contrast | Seed | Target(s) (peak coordinates) | Cluster size (# voxels) | Cluster p-FDR |
|---|---|---|---|---|
| Pre VO2-peak | R. Hippocampus∗ | R. Superior Frontal Gyrus (14, 2, 58) | 458 | 0.000005 |
| L. Precentral gyrus (-22, -6, 56) | 132 | 0.014 | ||
| R. Occipital cortex (28, -62, 58) | 116 | 0.017 | ||
| R. Frontal pole (22, 48, 32) | 116 | 0.017 | ||
| Neg pre VO2-peak | R. Hippocampus∗ | R. Thalamus (WM), (12, -28, 18) | 178 | 0.0047 |
| Occipital (WM) (22, -86, 0) | 145 | 0.012 | ||
| ICA S1M1 | L. Occipital Pole (2, -92, 18) | 133 | 0.0019 | |
| dVO2-peak | R. Hippocampus∗ | R. Angular Gyrus (36, -48, 30) | 197 | 0.0013 |
| L. Inf Frontal Gyrus (-48, 14, 6) | 105 | 0.022 | ||
| ICA DMN | L. Front. Orbital (-32, 30, -8) | 109 | 0.019 | |
| Neg dVO2-peak | L. Hippocampus | R. Precentral Gyrus (-36, -12, 36) | 139 | 0.0097 |
| ICA S1M1 | R. Thalamus (-6, -28, 12) | 114 | 0.0043 |
Target regions are labeled based on the locations of the largest number of voxels within significant cluster, as identified and labeled within the Conn-toolbox. ∗Seed region defined post hoc from VO2-peak predicted BOLDSTD effects at baseline.