Table 1.

Metabolites tentatively identified in NIH-III mice after administration of a single dose of SN30000.

			Mass spectrum (m/z)		Metabolite/SN30000 peak areac
ID	RRTa	λmaxb	Parent	Product ions	Plasma	Liver	Tumor
M1	0.23	252,300,400	347	100,133,228,260	0.18	NDd	0.19
M2	0.31	252,300,400	347	100, 228,260	0.03	ND	0.02
M3	0.51	245,325	315	100,210,228	0.07	0.55	0.12
M4	0.56	245,360	331	100,227,244	0.22	0.83	0.35
M5	0.67	255,345	313	100,156,226	0.05	0.64	0.04
M6	0.79	252,370	331	227,244	0.10	0.35	0.13
M7	0.89	252,300,400	305	117,198,214,244	0.06	0.17	0.06
M8	0.92	252,360	347	227,244	0.05	ND	0.04
M9	0.95	252,330	491	100,228,315	0.04	0.36	0.08
SN30000	1.00	252,300,400	331	100,212,244	1.00	1.00	1.00
M10	1.06	260,360	507	244,331	0.31	0.47	0.44
M11	1.15	252,320	273	212	0.04	0.34	0.06
M12	1.22	252,360	289	211,228	0.13	1.06	0.16
M13	1.23	245,325	289	100,212	0.08	1.50	0.11
M14	1.29	252,360	315	211,228	0.35	5.18	0.41
M15	1.38	252,360	331	211,228	0.26	0.21	0.24
M16	1.39	252,300,400	276	130,214,230,258	0.50	0.34	0.49
M17	1.67	245,320	244	142,168,198,226	0.11	0.12	0.14
M18	1.73	252,360	260	130,172,214,242	1.14	0.60	1.63
M19	1.81	252,360	329	112,172,200,228,311	0.03	0.27	0.02

For proposed structures, see Figure 1.

^aRetention time relative to SN30000.

^bAbsorbance maxima (nm), determined with an HPLC photodiode array detector.

^cValues are peak area ratios for representative animals based on absorbance detection at 252 nm, 30 min after i.p. dosing with SN30000 at 186 mg/kg.

^dND = Not detected by absorbance or MS.