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. 2017 Jul 30;2017:1917804. doi: 10.1155/2017/1917804

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Copyright © 2017 Wei Ren et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IL-22 induced obvious inhibition of ALI induced by AngII. (a) All mice showed ALI after AngII treatment, and IL-22 could decrease the incidence of ALI. (b) In the AngII group, obvious pulmonary edema was noticed in the lung tissues. (c) Presence of massive infiltration of neutrophils (MPO) and macrophages (CD68). Such phenomenon was completely reversed after IL-22 treatment. AG490 could obviously inhibit the pulmonary protective effects of IL-22. The HE images were observed under a magnification of 100x. The immunohistochemistry images were observed under a magnification of 200x. ^∗P < 0.05, versus the control group; ^#P < 0.05, versus the AngII group; ^&P < 0.05, versus the AngII + IL-22 group.