Table 2.
Table showing results of the TF array, indicating the amount of increase in active transcription factor in cells that were exposed to MCAA serum relative to cells exposed to cleared serum. The 9 bolded pathways have a greater than two-fold increase and have bindings sites to the COL1A1 promoter.
| Pathway | Fold Change |
Pathway | Fold Change |
|---|---|---|---|
| AP1 | 1.664 | NF-1 | 6.346 |
| AP2 | 1.206 | NFAT | 1.318 |
| AR | 1.934 | NF-E2 | 0.361 |
| ATF2 | 1.883 | NFkB | 1.558 |
| Brn-3 | 0.810 | OCT. 4 | 1.715 |
| C\EBP | 16.166 | p53 | 1.372 |
| CAR | 1.500 | Pax-5 | 3.545 |
| CBF | 0.976 | Pbx1 | 1.714 |
| CDP | 1.763 | Pit | 0.471 |
| CREB | 0.839 | PPAR | 1.101 |
| E2F-1 | 1.981 | PXR | 2.695 |
| EGR | 1.463 | SMAD | 0.602 |
| ER | 1.610 | Sp1 | 0.880 |
| Ets | 1.642 | SRF | 1.356 |
| FAST-1 | 1.052 | SATB1 | 11.450 |
| GAS/ISRE | 1.509 | Stat1 | 1.029 |
| GATA | 5.866 | Stat3 | 1.443 |
| GR/PR | 2.424 | Stat4 | 0.746 |
| HIF | 9.016 | Stat5 | 2.231 |
| HNF4 | 0.404 | Stat6 | 0.864 |
| IRF | 0.943 | TCF/LEF | 1.190 |
| MEF2 | 1.125 | TR | 0.520 |
| Myb | 1.923 | YY1 | 1.148 |
| Myc-Max | 2.602 | TFIID | 7.440 |