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. 2005 Mar 11;102(12):4536–4541. doi: 10.1073/pnas.0406030102

Fig. 4.

Fig. 4.

Molecular mechanism of CCL3-induced sensitization. (A) Pretreatment of DRG neurons with PTX impairs CCL3-induced sensitization of TRPV1. *, P < 0.011. (B) Pretreatment of DRG neurons with U73122 blocks CCL3-induced sensitization of TRPV1. **, P < 0.017. (C) Treatment with chelerythrine chloride impairs CCL3-induced sensitization of TRPV1. ***, P < 0.05. D CCL3 induces PKC translocation in a subpopulation of DRG neurons. All responses were evoked by using 0.15 μM CAP. Percent of cells exhibiting change in PKC isotype localization is indicated at bottom. Data in A–C were analyzed by using one-way ANOVA and are presented as mean ± SEM from four independent experiments.