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Intraplantar CCL3 enhances hot-plate sensitivity in the mouse. Change in hot-plate (54°C) escape latency is plotted at the indicated times after intraplantar injection of one hind paw with saline (filled squares) or CCL3 (250 ng, filled circles) (n = 8 mice per group) *, P < 0.05, **, P < 0.01, ANOVA followed by the Newman–Keuls test at each time point.
