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Cysmethynil, a small-molecule inhibitor of Icmt. (A) Structure of the indole-based compound, cysmethynil. (B) Time-dependent inhibition of Icmt by cysmethynil. Icmt activity was measured as the incorporation of [3H] from [3H]AdoMet into the Icmt substrate BFC. The assay was performed either with (○) or without (•) preincubating Icmt with cysmethynil as described in Materials and Methods.
