Fig. 3.

The SMPD3-deficient mouse develops dwarfism. (A) Comparison of e14 embryos smpd3^–/–, smpd^+/–, and smpd^+/+ siblings. (B) Severe postnatal growth retardation of p7 wt male smpd3^–/– and wt p7 male littermates. (C) Growth curves of wt, smpd3^+/–, and smpd3^–/– male (n = 10) and female (n = 10) littermates during postnatal development. (D) Hypoplasia of spleen, kidney, liver, heart, and brain of –/– and +/+ p10 and p20 mice. (E) Weight of organs of control ^+/+ and smpd3^–/– of p10 and p20 mice. Generalized hypoplasia in the smpd3^–/– mouse. (F–H) Serum IGF1 concentration of wt and smpd3^–/– male siblings, n = 10 (F); cell count of splenocytes (n = 4 control and 4 smpd3^–/– male mice) at 1, 6, and 24 mo of age (G); and cell count of pituicytes of control (n = 4) and smpd3^–/– (n = 4) male mice at 1 and 24 mo of age (H).