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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Mar 21;45:24–31. doi: 10.1016/j.conb.2017.02.014

Figure 2.

Figure 2

miRNAs are regulated by neural activity. Neural activity-dependent Drosophila miR-1000 regulates glutamate release by targeting Vglut in axons. In dendrites, NMDAR regulates miR-129 (targeting Kv1.1), miR-138 (targeting Lypla1), and miR-501-3p (targeting GluA1); mGluR regulates miR-125a (targeting PSD95), miR-125b (targeting GluN2A), and miR-137 (targeting GluA1); TTX and APV increase miR-124 which suppresses GluA2; miR-223 regulates GluA2 and GluN2B to prevent neuronal excitotoxicity.