Fig. 5.

The proposed model for conformational change around the catalytic site. (a) Reaction scheme in the catalysis and rotation model. Three green circles represent the catalytic state, and the red arrow indicates the angle of the γ-subunit. States D and E represent the ADP-inhibited form and forward-rotated form, respectively. (b) Schematic model of the conformational change around the catalytic site with the inhibitory ADP coupled with mechanical rotation. Upon forced rotation, the catalytic site progressively opens its conformation-breaking interactions with ADP.