Table 3.

Multivariable analysis for the association between TIAE or desaturation to SpO₂ < 80%, any TIAE, severe TIAE) and Mid-term outcomes (ICU mortality, duration of ICU stay, duration of mechanical ventilation)

	ICU mortality (Odds ratio, 95% CI)			Duration of ICU stay (% increase, 95% CI)			Duration of mechanical ventilation (% increase, 95% CI)
Any TIAE or desaturation<80%*	1.11	(0.88, 1.41)	P=0.38	7%	(−1, 16)	P=0.10	12%	(4, 21)	P=0.004
No event	baseline			baseline			baseline
Any TIAE**	1.09	(0.82, 1.46)	P=0.54	1%	(−7, 12)	P=0.69	8%	(−2, 19)	P= 0.10
No TIAE	baseline			baseline			baseline
Severe TIAE***	1.80	(1.24, 2.60)	P=0.002	8%	(−6, 26)	P=0.28	15%	(−1, 33)	P=0.063
No severe TIAE	baseline			baseline			baseline

TI: tracheal intubation; TIAE: tracheal intubation associated event

Total N=4,671

A multivariable regression model for each event category (any TIAE or desaturation<80%, any TIAE, or severe TIAE) included patient level covariates associated with event category. Each 3 event category was used an independent variable and each 3 outcome variable (ICU mortality, Duration of ICU stay, Duration of mechanical ventilation) was used a dependent variable, therefore this table demonstrates results from a total of 9 multivariable logistic regression models.

^*N=3,841 for ICU mortality and overall model was significant (p<0.0001).

N=3,718 for ICU length of stay and overall model was significant (p<0.0001), R-square=0.1244. N=3,192 for duration of mechanical ventilation, overall model was significant with p<0.0001, R-square =0.0581. This model included the following patient-level covariates associated with any TIAE or desaturation (Age, PIM2 score, Diagnosis category, Indication, History of difficult airway, Upper airway obstruction)

^**N=3,841 for ICU mortality and overall model was significant (p<0.0001). N=3,718 for ICU length of stay and overall model was significant (p<0.0001), R-square= 0.1201. N=3,192 for duration of mechanical ventilation, overall model was significant with p<0.0001, R-square = 0.0515. This model included the following patient-level covariates associated with any TIAE (Age, PIM2 score, Diagnosis category, Indication, History of difficult airway, Upper airway obstruction)

^***N=3,841 for ICU mortality and overall model was significant (p<0.0001). N=3,718 for ICU length of stay and overall model was significant (p<0.0001), R-square= 0.1189. N=3,192 for duration of mechanical ventilation, overall model was significant with p<0.0001, R-square =0.0512. This model included the following patient-level covariates associated with severe TIAE (Age, PIM2 score, Diagnosis category, Indication, Upper airway obstruction).

The analysis with Any TIAE or desaturation vs. Duration of mechanical ventilation shown at the top right corner is further described in details in Table 4.

The analysis with severe TIAE vs. ICU mortality shown at the bottom left corner is described in details in Table 5.