Table 4.

Multivariable analysis for the association between TIAE or desaturation<80% and duration of mechanical ventilation

Factors	% increase in duration of mechanical ventilation	95% CI	p-value
TIAE or desaturation<80%	12%	(4%, 21%)	0.004
Age in year
Infant	Reference
Child (1–7 year)	−6%	(−14%, 3%)	0.164
Older child (8–17 year)	−9%	(−18%, 1%)	0.063
PIM2 score	0.4%	(0.1%, 0.7%)	0.014
Diagnosis
Respiratory	28%	(14%, 44%)	<0.001
Neurological	−11%	(−23%, 2%)	0.100
Cardiac	4%	(−9%, 19%)	0.54
Sepsis	16%	(−3%, 38%)	0.098
Indication for tracheal intubation*
Respiratory Failure	12%	(2%, 22%)	0.012
Hemodynamic Instability	5%	(−7%, 18%)	0.441
Procedural	−31%	(−39%, −22%)	<0.001
Upper Airway Obstruction	−19%	(−28%, −8%)	0.001
Therapeutic hyperventilation	3%	(−25%, 42%)	0.838
Pulmonary Toilet	21%	(4%, 41%)	0.016
Difficult airway features
History of Difficult Airway	7%	(−4%, 19%)	0.228
Upper Airway Obstruction	−3%	(−15%, 11%)	0.650

Total N= 3,192

Overall p<0.001, R-squared=0.0581

A multivariable linear regression model for TIAE or desaturation<80%, included covariates associated with occurrence of TIAE or desaturation<80% (age, diagnosis, indication for respiratory failure, indication for shock, procedural indication, indication for upper airway obstruction, indication for therapeutic hyperventilation, indication for pulmonary toileting (suctioning and clearance of secretions), and difficult airway features including history of difficult airway and symptom of upper airway obstruction) and PIM2 score. The duration of mechanical ventilation is normalized by natural log transformation. The association with occurrence of TIAE or desaturation<80% in univariate analysis with p=<0.1 was used for covariates inclusion criteria.

^*Patients may have more than one indication for TI