Table 1.

Indications and contraindications of trans-arterial chemoperfusion

Indications

Unresectable liver metastases

Liver-dominant metastatic disease

Minimum of three different chemotherapies before

No systemic chemotherapy available

Symptomatic liver metastases

Contraindications

ECOG >1

Tumour burden of the liver > 75%

Poor liver function (quick < 40%, PTT < 45 s, albumin < 2 g/dL)

Extensive amounts of ascites

Obstructive icterus (bilirubin > 3 mg/dL)

Acute infection

Myelodepression (leucocytes < 2000/mL, platelets < 100000/μL)

Limited kidney function (creatinine > 2 mg/dL)

Extensive heart insufficiency ( > NYHA II)

ECOG: Eastern Cooperative Oncology Group; PTT: Prothrombin time test; NYHA: New York Heart Association.