Figure 3.

On-target efficacy of proteasome inhibitors and synergistic activity with artemisinin. (A) On-target studies with the synchronized trophozoite parasites for the indicated analogs. (B) Artemisinin IC₅₀, as determined by 72 h SYBR green assay, of Dd2 parasites when co-treated with the indicated concentrations of carmaphycin B. (C) Artemisinin IC₅₀, as determined by 72 h SYBR green assay, of Dd2 parasites when co-treated with the indicated concentrations of analog 18. IC₅₀ results are presented as the mean ± SEM with n = 2, with one representative regression curve shown.