Table 3. Calculation of Inactivation Kinetics for Carmaphycin B and Analogs 1 and 18.
c20S |
Pf20S |
|||||
---|---|---|---|---|---|---|
CarB | 1 | 18 | CarB | 1 | 18 | |
kinact (s–1) | 1.68 × 10–3 | 5.62 × 10–3 | 6.2 × 10–4 | 1.92 × 10–4 | 1.76 × 10–3 | 5.88 × 10–5 |
KI (nM) | 374.9 | 3744 | 39 213 | 222.6 | 2294 | 371.7 |
kinact/KI (M–1 s–1) | 4481 | 1500.3 | 15.8 | 864.3 | 767.7 | 158.1 |