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. 2017 Jul 11;60(15):6721–6732. doi: 10.1021/acs.jmedchem.7b00671

Table 3. Calculation of Inactivation Kinetics for Carmaphycin B and Analogs 1 and 18.

  c20S
Pf20S
  CarB 1 18 CarB 1 18
kinact (s–1) 1.68 × 10–3 5.62 × 10–3 6.2 × 10–4 1.92 × 10–4 1.76 × 10–3 5.88 × 10–5
KI (nM) 374.9 3744 39 213 222.6 2294 371.7
kinact/KI (M–1 s–1) 4481 1500.3 15.8 864.3 767.7 158.1