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. 2017 Jun 21;8(8):792–796. doi: 10.1021/acsmedchemlett.7b00205

Scheme 1. Synthetic Pathway to Compounds EMAC 8000a–m.

Scheme 1

Reagents and conditions: (a) H2SO4/MeOH; (b) NH2NH2 H2O, MeOH; (c) substituted benzaldehydes, 2-propanol/CH3COOH; (d) acetic anhydride/pyridine.