. 2017 Jul 5;8(8):864–868. doi: 10.1021/acsmedchemlett.7b00212

Table 2. IC₅₀ Values of Test Compounds in the PGE₂/PGD₂ and LTB₄ Assays.

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Inhibition of COX pathway as determined by LC–MS/MS analyses of the combined production of COX-derived PGD₂ and PGE₂ in RBL-1 cells upon stimulation with arachidonic acid in the presence or absence of test compounds.

Inhibition of 5-LOX pathway as determined by LC–MS/MS analyses of the production of 5-LOX-derived LTB₄ in RBL-1 cells upon stimulation with arachidonic acid in the presence or absence of test compounds. *The data represent the calculated IC₅₀ values and associated 95% confidence intervals as determined from triplicate samples at each concentration after a sigmoidal curve fit using GraphPad Prism software.

Table 2. IC50 Values of Test Compounds in the PGE2/PGD2 and LTB4 Assays.

Table 2. IC₅₀ Values of Test Compounds in the PGE₂/PGD₂ and LTB₄ Assays.