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In vivo antiviral activity of 14. (A) Survival rate. (B) Mice body weight. (C) Clinical score. Three-day-old ICR mice are i.p. inoculated with EV71 and administrated with vehicle (N = 10), lycorine (0.4 mpk, N = 10), 14 before EV71 infection (10 mpk, N = 10), 14 after EV71 infection (10 mpk, N = 9), and ribavirin (100 mpk, N = 11, or 50 mpk, N = 12).
