Table 5. Single Dose Mouse in Vivo PK Properties^a.

Compd	11	14	NLD
iv@1 mpk
Cl (mL/min/kg)	36	34	105
T1/2 (h)	1.6	1.5	0.3
Vd (L/kg)	3.2	2.8	2.4
AUC (nM·h)	592	821	371
ip@5 mpk
Cmax (nM)	1443	2152	1558
Tmax (h)	0.5	0.7	0.3
AUC (nM·h)	2449	3868	1711
%F	79	88	92

^aData reported are the means from the dosing cohorts (Male CD-1 mouse, n = 3/dose). Dosed at 2 mg/kg iv (20% solutol in water) and 5 mg/kg ip (20% solutol in water). Cl is clearance. Vd is volume of distribution. C_max represents the highest observed concentration. T_max is the time taken to reach the maximum concentration. T_1/2 is the half-life of the compound exposure in plasma. AUC is the area under the curve. %F is percent bioavailability.