Table 1.

Cases of pravastatin-induced adverse effects and P-glycoprotein interactions.

Reported case of pravastatin-induced adverse effect	Other medications taken by patient	P-glycoprotein effect	References
Lichenoid drug eruption in 64-year-old woman [12]	Aspirin	Possible inducer	[13]
	Candesartan	—
	Clopidogrel	Substrate	[9]
	Diltiazem	Substrate, inhibitor, inducer	[9, 14]
	Furosemide	—
	Hydralazine	—
	Isosorbide mononitrate	—
	Insulin	Inducer	[14]
	Metformin	—
Diffuse, pruritic rash in a 55-year-old woman [15]	Aripiprazole	Substrate	[16]
	Lorazepam	—
	Sertraline	Substrate and inhibitor	[9, 14, 16]
	Olanzapine	Substrate	[16]
	Quetiapine	Substrate	[16]
	Lithium carbonate	—
	Levothyroxine	Inducer	[17]
	Magnesium	—
Acute myopathy in a 65-year-old woman [18]	Aspirin	Possible inducer	[13]
	Colchicine	Substrate, inducer	[14, 18]
	Spironolactone	Inhibitor	[19]
	Furosemide	—
	Losartan	Substrate, inhibitor	[9, 14]
Pruritic, psoriasis-like eczematous eruption in an 82-year-old man (current case)	Allopurinol	—
	Aspirin	Possible inducer	[13]
	Colchicine	Substrate, inducer	[14, 18]
	Hydrochlorothiazide	—