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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Cell Rep. 2017 Jul 11;20(2):319–332. doi: 10.1016/j.celrep.2017.06.046

Figure 4.

Figure 4

Cocaine- or cocaine-associated cue-induced drug-seeking behavior in WT and mGluR2-KO rats. (A) Active and inactive lever responding during extinction, illustrating lower extinction responding and lower cocaine-triggered reinstatement responding in mGluR2-KO rats. (B) Active and inactive lever responding during the last 3 sessions of cocaine self-administration and when animals were re-exposed to the previous cocaine self-administration chambers after 2, 7 or 14 days of withdrawal, illustrating a progressive reduction in cue-induced cocaine-seeking over time of withdrawal in mGluR2-KO rats. The data are represented as mean ± SEM. *p<0.05; **p<0.01 compared with WT control group.