Table 2.
Baseline prevalence of pyrazinamide resistance among subjects in a TB cohort study in Lima, by baseline resistance pattern.
Resistance pattern | Total No. |
PZA resistance No. |
% PZA resistance % (95% CI) |
---|---|---|---|
Pan-susceptible to all FLD | 2191 | 0 | 0 (0–0.2)* |
Monoresistant | 466 | 3 | 0.6 (0.1–1.9) |
Polyresistant to FLD, not MDR-TB | 213 | 21 | 9.9 (6.2–14.7) |
Resistant to two FLD | 187 | 9 | 4.8 (2.2–8.9) |
Resistant to three or more FLD | 26 | 12 | 46.2 (26.6–66.6) |
MDR-TB | 405 | 193 | 47.7 (42.7–52.6) |
Incomplete DST to FLD† | 2 | 0 | 0 (0–84.2)* |
Total | 3277 | 217 | 6.6 (5.8–7.5) |
DST=drug susceptibility testing; FLD=first-line drugs (isoniazid, rifampin, ethambutol, pyrazinamide, and streptomycin); MDR-TB=multidrug-resistant tuberculosis; PZA=pyrazinamide.
One-sided, 97.5% confidence interval.
One patient had missing DST to rifampin and streptomycin, and another patient had missing DST to streptomycin.