Figure 5. GBM tumors reoccur after TMZ treatment.
Animals were transplanted with GBM9 cells and treated with TMZ for 5 days from 5 to 10 dpt. Control transplanted animals not treated with TMZ at (A) 5 dpt and (A′) 10 dpt. (B) Zebrafish treated continuously from 5 to 10 dpt with 50 μm TMZ. (B) Zebrafish before TMZ treatment at 5 dpt. (B′) Zebrafish at 10 dpt immediately after 5 days of TMZ treatment. (B″) Zebrafish at 15 dpt, 5 days after the end of treatment. (B‴) Zebrafish at 20 dpt, 10 days after the end of treatment. n = 5 animals per group.
