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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Chem Rev. 2016 Jun 17;116(14):7818–7853. doi: 10.1021/acs.chemrev.6b00024

Figure 15.

Figure 15

Bacteria appear to have evolved oxidative cyclization enzymes to enforce the cis configuration, in which counteranion and cation binding is favored by the protonated and neutral forms of the molecules, respectively.