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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Cancer Res. 2010 Nov 2;70(22):9012–9021. doi: 10.1158/0008-5472.CAN-10-0360

Figure 5.

Figure 5

(A) Optical image of a small part of a representative MDA-MB-231 tumor, stained with H&E after concluding a MetA-SIMS experiment with (1) necrotic region and (2) viable tumor areas selected. (B) Na+ shown in blue and (C) K+ distribution shown in gray from MetA-SIMS data and overlay with microscopic image in regions (1) and (2) are shown in the upper panel; the individual ion distributions in areas (1) and (2) are shown in the bottom panel. Due to previous gold coating of the tissue, the hematoxylin staining was less efficient, and therefore the visibility of cell nuclei is less pronounced. Scale bar: (A) 100 μm; (B) and (C) 25 μm.