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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Eur J Immunol. 2016 Apr 15;46(6):1490–1503. doi: 10.1002/eji.201545663

Figure 6. Working model for regulation of CD5 expression in T cells.

Figure 6

CD5 expresses three alternatively polyadenylated CD5 mRNA isoforms that differ in their 3′ UTR length, all contributing for CD5 protein production by different levels. Signaling through the TCR leads to an increase in CD5 mRNAs levels and, in comparison to resting conditions, the shorter isoforms levels are specifically increased. PTBP1 increases the levels of the shorter mRNA either by preferential use of the proximal PAS or by stabilizing this mRNA isoform. The longer CD5 mRNA isoform is targeted by miR-204. These concerted mechanisms of APA, PTB and miR-204 fine-tune CD5 expression during T-cell activation.