Table 1. Percent changes in surface pMHC levels after inhibition of various intracellular processes hypothesized to be affected by Mtb.
| Hypothesis: affected process | 0.1 h, % | 1.0 h, % | 10 h, % | 100 h, % |
|---|---|---|---|---|
| H1: Antigen processing | ↓ 47 | ↓ 8.4 | ↓ 7.2 | ↓ 43 |
| H2: MHC class II maturation | ↓ 1.4 | ↓ 8.2 | ↓ 49 | ↓ 69 |
| H3: MHC class II peptide loading | ↓ 44 | ↓ 11 | ↓ 12 | ↓ 57 |
| H4: MHC class II transcription | ↓ 0.0026 | ↓ 0.16 | ↓ 26 | ↓ 66 |
| H1 plus H4 | ↓ 47 | ↓ 8.6 | ↓ 31 | ↓ 81 |
| H2 plus H3 | ↓ 45 | ↓ 18 | ↓ 55 | ↓ 86 |
Identical experimental conditions were used in each simulation, and comparisons were made to the baseline model, i.e. when no processes were inhibited.