Table 2. Additional intracellular processes significantly correlated with surface pMHC levels.
| Time, h | Description (correlation coefficient) |
|---|---|
| 1.0 | MHC class II export (0.79) |
| Antigen concentration in medium (0.41) | |
| Antigen uptake (0.40) | |
| H2 (0.38) | |
| IFN-γ stimulation of translation* (0.33) | |
| 10 | H2 (0.72) |
| IFN-γ stimulation of translation* (0.62) | |
| MHC class II export (0.55) | |
| IFN-γ receptor-ligand binding (0.52) | |
| IFN-γ concentration in medium (0.52) | |
| H4 (0.49) | |
| CIITA translation (0.44) | |
| IFN-γ stimulation of transcription† (0.36) | |
| CIITA transcription (0.36) | |
| 100 | H4 (0.57) |
| H2 (0.56) | |
| CIITA translation (0.56) | |
| CIITA transcription (0.53) | |
| IFN-γ concentration in medium (0.51) | |
| IFN-γ receptor-ligand binding (0.49) | |
| IFN-γ stimulation of transcription† (0.47) | |
| Antigen concentration in medium (0.36) | |
| Antigen uptake (0.33) | |
| MHC class II export (0.32) | |
| IFN-γ degradation in solution (-0.87) | |
| MHC class II degradation (-0.56) | |
| CIITA protein degradation (-0.53) | |
| CIITA mRNA degradation (-0.49) | |
| IFN-γ receptor-ligand dissociation (-0.48) |
One thousand simulation runs were performed using different sampled parameter values. PRCC values determined to be significant (P ≤ 10-30) are shown in parentheses. Intracellular processes considered in previous hypotheses (H1-H4) are italicized.
*
MHC class II translation.
†
CIITA transcription.