Table 1.

MG23 gating is revealed by pathophysiological concentrations Zn²⁺

Shown are the mean Gaussian fits of paired all-points-amplitude histograms constructed from bilayer experiments using native SR vesicle preparations in the absence and presence of 1 nm Zn²⁺. Bilayers were voltage-clamped at 0 mV, and Ca²⁺ was the permeant ion. Data are displayed as the mean ± S.D., n = 3.

Experiment number	Gaussian fits of all-points-amplitude histograms
	Control			1 nm Zn2+
	Peak 1	Peak 2	Peak 3	Peak 1	Peak 2	Peak 3
	pA			pA
Bilayers containing RyR2 and MG23
1	−0.65	−3.78		−0.167	−2.53	−3.76
2	−0.39	−4.24		−0.489	−1.62	−4.41
3	−0.36	−4.07		0.3	−1.87	−4.4
Mean ± S.D.	−0.47 ± 0.2	−4.03 ± 0.2		−0.12 ± 0.4	−2 ± 0.5	−4.19 ± 0.4
Bilayers containing RyR2 only
1	−0.38	−4.22		−0.41	−3.8
2	−0.25	−3.88		−0.04	−4.22
3	0.06			−0.31	−4.14
Mean ± S.D.	−0.19 ± 0.2	−4.05 ± 0.2		−0.25 ± 0.2	−4.05 ± 0.2