Table 1.
Peptides used in this study
Lysine residues were added at N and C termini for TLR6/4N and TLR4/6C peptides, respectively. Toxicity is represented by LD50 values for each peptide. Lysine residues (lowercase k) were added to the peptides to increase solubility.
| Designation | Sequence | Toxicity |
|---|---|---|
| μm | ||
| TLR-derived peptides | ||
| TLR4N1 | kkMYKTIISVSVVSVIVVS | >80 |
| TLR4N2 | kkVIVVSTVAFLIYHFYFH | >80 |
| TLR4C1 | AFLIYHFYFHLILIAGkk | >80 |
| TLR4C2 | HFYFHLILIAGCKKYS | >80 |
| TLR6N1 | kkSPLSCDTVLLTVTIGAT | >80 |
| TLR6N2 | kkTVLLTVTIGATMLVLAV | >80 |
| TLR6C1 | TIGATMLVLAVTGAFLCkk | >80 |
| TLR6C2 | GAFLCLYFDLPWYVRMLkk | >80 |
| Control peptides | ||
| scrTLR4C | SLICYKIYHAFKLHGF | >80 |
| scrTLR6C | MWLYKCPRLGFLKAYDVFL | >80 |
| scrTLR2C | kkGFGLHIRVWLHLLTLCkk | >80 |