Table 1.
Demographic background and clinical characteristics of the subjects for modeling.
| Characteristics | Number or mean ± SD | Median (range) |
|---|---|---|
| No. patients | 178 | — |
| No. observations | 208 | — |
| Observations per patient | 1–4 | — |
| Dose (ng) | 156730.34 ± 27835.12 | 18000 (50000–180000) |
| Sampling time after dosing (h) | — | 141.5 (15–13958) |
| GNDR, n (%) | ||
| Male | 99 (55.62) | — |
| Female | 79 (44.38) | — |
| Age (year) | 48.40 ± 12.91 | 50.5 (15–75) |
| Body weight (kg) | 65.52 ± 11.74 | 64 (42.5–100) |
| Alanine transaminase (U/L) | 34.79 ± 26.36 | 26.5 (3–150) |
| Aspartate transaminase (U/L) | 37.65 ± 21.01 | 31 (14–149) |
| Creatinine clearance (mL/min) | 91.39 ± 24.33 | 91.66 (44.80–166.87) |
| Serum creatinine (μmol/L) | 74. 65 ± 12.42 | 73 (44–106) |
| Body mass index (kg/m2) | 23.41 ± 3.48 | 23.33 (15.43–33.80) |
| Height (cm) | 166.89 ± 7.95 | 168 (145–191) |