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Relation between estimated 24-hour urinary sodium excretion using the Tanaka equations and MRI outcomes from months 6 through 60. (A) relative rate of CNAL, (B) change in T2 lesion volume, (C) change in brain volume. Estimates are adjusted for age, sex, randomization status (IFNB-1b, placebo), CIS onset type (multifocal, monofocal), 25-hydroxyvitamin D status, and body mass index.
