Figure 2.
Cartoon showing the regulation of Ca2+ signaling in microglia by a selected number of ion channels and receptors. (Abbreviations: KV, voltage-gated K+ channel; Kir, inward-rectifier K+ channel; KCa, calcium-activated K+ channel; IP3, ionositol-triphosphate; Orai1, calcium release-activated calcium channel protein 1; P2R, purinergic receptor; SERCA, sarco/endoplasmic reticulum Ca-ATPase; STIM, stromal interaction molecule; TRP, transient receptor potential channel). Activation of K+ channels hyperpolarizes the microglia membrane and thus facilitates Ca2+-influx through Ca2+ and cation channels.