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. 2017 Mar 1;11(4):281–304. doi: 10.1080/19336950.2017.1299835

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Figure 4. — Application of SK channel antagonists alters adaptation and frequency tuning of ELL pyramidal cells to changes in stimulus mean (i.e., 1^st order). (A) Firing rate responses (middle) of an ON-type pyramidal cell to a 1^st order step stimulus (blue, top) under control (green) conditions and after application of an SK antagonist (orange). The antagonist increased the time constant and decreased the level of adaptation. (B) Frequency tuning (middle) of an ON-type pyramidal cell to a 1^st order sinusoidal stimulus (blue, top) under control (green) conditions and after SK channel antagonist application (orange). SK channel antagonist application increased tuning to low frequencies, thereby lowering the frequency at which frequency tuning is maximum (compare position of green and orange arrows).