Figure 9.
Is SK channel regulation a key determinant of adaptive optimized coding of natural stimuli? (A) Summary showing that SK1 channels present on the apical dendritic trees of ELL pyramidal cells (left) regulate frequency tuning (middle) and adaptation (right) to 2nd order stimuli. Increasing the total SK1 channel conductance will make the neural tuning curve more high-pass (middle) by increasing the degree of adaptation (right). (B) Following a change in stimulus statistics (left), neural tuning should also progressively adapt (middle, compare black and magenta curves) such as to optimize coding of the new stimulus (right, compare dashed and solid curves). (C) Same as B but for another change in stimulus statistics.