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Correlation of potencies of 18 TP as inducers of NQO1 in Hepa1c1c7 murine hepatoma cells, expressed as CD values, and for suppression of iNOS induction by IFN-γ in primary mouse macrophages, expressed as IC50 values. The linear correlation coefficient is r2 = 0.91. TP-230 is the butyl ester of CDDO, TP-241 is the piperidyl amide derivative of CDDO, and TP-218 is the ethyl ester of CDDO. Other structures are shown in Fig. 1.
