Table 4.
SHM-positive* | Not tested | |
---|---|---|
B lymphocyte-specific | Igκ, IgH, Pax5, Bcl6*, mb-1 (Igα), B29(Igβ) | VpreB, EBF, λ5, AID |
T lymphoyte-specific | TCRβ | TCRα, TCRγ, TCRδ, CD4, CD5, preTα |
SHM-positive genes have been reported to have SHM in normal B cells, B cell lymphoma in human, and T cell lymphoma in AID Tg mouse.
From an in silico motif search (43).