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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Vaccine. 2011 Apr 2;29(23):4003–4007. doi: 10.1016/j.vaccine.2011.03.067

Table 1.

Vaccination with H9 HA VLP vaccine lowers frequencies of virus isolation from SPF chickens challenged with wild type H9N2 AIV.a

Group Virus isolationb/total
Trachea Cecal tonsil
VLP 2 μg + ISA70 1/10** 2/10*
VLP 5 μg + ISA70 2/10** 2/10*
VLP 10 μg + ISA70 0/10*** 0/10***
VLP 20 μg + ISA70 0/10*** 0/10***
VLP 20 μg only 7/10 3/10*
Commercial vaccinec 0/10*** 0/10***
Challenge control 9/10 8/10
a

Groups of SPF chickens were challenged intranasally with 106 EID50 of homologous H9N2 virus at 3 weeks post vaccination.

b

Virus re-isolation was done by chicken embryo inoculation at 5 days post challenge.

c

Commercial vaccine contains identical AIV strains and mineral-oil adjuvant.

*

p < 0.05 by Fisher’s exact test, compared to challenge control group.

**

p < 0.01 by Fisher’s exact test, compared to challenge control group.

***

p < 0.001 by Fisher’s exact test, compared to challenge control group.