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. Author manuscript; available in PMC: 2018 Jul 22.
Published in final edited form as: Biochem Biophys Res Commun. 2017 May 25;489(2):223–227. doi: 10.1016/j.bbrc.2017.05.137

Fig. 3.

Fig. 3

Progressive hearing loss extending speed and frequency difference of hearing loss in Cx26-Prox1 cKO mice. A: ABR threshold increase at different frequencies in Cx26 cKO mice. Asterisks with different colors represent the earliest occurring time of significant increase in ABR thresholds at different frequencies. B: The speed of progressive hearing loss from high-frequencies to low-frequencies in Cx26 cKO mice. Earliest occurrence of significant increases in ABR thresholds at different frequencies was plotted with mouse age. A solid line represents common logarithmic function fitting, showing as linear fitting in the plot with a common logarithmic scale in frequency: log y (Frequency, kHz) = 2.087−0.0198 * × (postnatal day), r=0.998. C: Progressive increases in ABR thresholds at different frequencies in Cx26 cKO mice with mouse age. Asterisks with different colors represent the earliest occurring time of significant increase in ABR thresholds at different frequencies. **: P<0.01, one-way ANOVA with a Bonferroni correction.