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. Author manuscript; available in PMC: 2017 Oct 19.
Published in final edited form as: ACS Chem Neurosci. 2016 Aug 8;7(10):1463–1468. doi: 10.1021/acschemneuro.6b00212

Scheme 1. Synthesis of BTX analogue compounds.a.

Scheme 1

a(a) benzoyl chloride, DMAP, CH2Cl2, 95%; (b) 1-naphthoyl chloride, DMAP, CH2Cl2, 89%; (c) (ethyl carbonic) 2,4-dimethyl-1H-pyrrole-3-carboxylic anhydride, i-Pr2NEt, 1,4-dioxane, 90 °C, 72%; (d) cyclohexanecarboxylic(ethyl carbonic) anhydride, 1,4-dioxane, 90 °C, 65%; (e) butyric(ethyl carbonic) anhydride, 1,4-dioxane, 90 °C, 75%; (f) BODIPY® FL propionic acid, 2-methyl-6-nitrobenzoic anhydride, Et3N, DMAP, CH2Cl2, 33%.