Table 3.
Characteristics of 15 lesions with local progression after SAbR
| Lesion | Tx site | Site description | Regimen | BED by USC | BED by LQ | Time from Dx to SBRT |
Prognostic group |
|---|---|---|---|---|---|---|---|
| 1 | Osseous, nonspine | Sacrum | 8 Gy × 1 fx | 32.02 | 32.33 | >1 y | Intermediate |
| 2 | Osseous, spine | T9 spine | 20 Gy × 1 fx | 108.95 | 172.09 | >1 y | Intermediate |
| 3 | Osseous, spine | T10 spine | 20 Gy × 1 fx | 108.95 | 172.09 | >1 y | Intermediate |
| 4 | Thorax | Lung RUL | 10 Gy × 3 fx | 134.54 | 144.07 | >1 y | Intermediate |
| 5 | Osseous, spine | T5 spine | 4 Gy × 4 fx | 40.32 | 40.33 | <1 y | Unfavorable |
| 6 | Osseous, nonspine | L mandible | 4 Gy × 5 fx | 50.40 | 50.42 | >1 y | Favorable |
| 7 | Soft tissue | T9 paraspinal | 4.5 Gy × 5 fx | 60.98 | 61.00 | >1 y | Intermediate |
| 8 | Osseous, nonspine | Sacrum | 5 Gy × 5 fx | 72.50 | 72.53 | >1 y | Intermediate |
| 9 | Osseous, spine | T9 spine | 5 Gy × 5 fx | 72.50 | 72.53 | >1 y | Favorable |
| 10 | Osseous, spine | T12 spine | 6 Gy × 5 fx | 98.40 | 98.44 | <1 y | Intermediate |
| 11 | Osseous, spine | T4 spine | 6 Gy × 5 fx | 98.40 | 98.44 | <1 y | Intermediate |
| 12 | Osseous, spine | T7-T8 spine | 8 Gy × 5 fx | 160.12 | 161.67 | >1 y | Intermediate |
| 13 | Soft tissue | R neck | 8 Gy × 5 fx | 160.12 | 161.67 | >1 y | Intermediate |
| 14 | Soft tissue | Occipital | 8 Gy × 5 fx | 160.12 | 161.67 | >1 y | Intermediate |
| 15 | Osseous, spine | L1-L2 spine | 8 Gy × 5 fx | 160.12 | 161.67 | >1 y | Intermediate |
| Systemic therapy |
Prior irradiation |
All lesions Tx’d at SAbR |
Systemic disease progression |
Additional information |
|---|---|---|---|---|
| ≥2 | Yes | No | Yes | Palliative dose |
| 1 | No | No | Yes | Inadequate coverage (invading spinal canal) |
| ≥2 | No | No | Yes | Inadequate coverage (proximity to cord) |
| 2 | No | Yes | No | Large tumor size |
| 0 | No | No | Yes | Palliative dose |
| ≥2 | Yes | No | Yes | Palliative dose |
| 1 | Yes | No | Yes | Palliative dose |
| ≥2 | Yes | No | Yes | Palliative dose |
| 1 | No | No | Yes | Palliative dose |
| 0 | No | No | Yes | Palliative dose |
| 1 | No | No | Yes | Palliative dose |
| 0 | No | Yes | Yes | Inadequate coverage (invading spinal canal) |
| 2 | No | No | Yes | Inadequate coverage (reduced PTV margin), ≥10 lesions |
| 2 | No | No | Yes | Inadequate coverage (reduced PTV margin), ≥10 lesions |
| 2 | No | Yes | No | Inadequate coverage (overlapping prior irradiation field) |
Abbreviations: BED = biologically equivalent dose; Dx = diagnosis; fx = fraction; L = left; LQ = linear quadratic model; PTV = planning target volume; R = Right; RUL = right upper lobe; SAbR = stereotactic ablative radiation therapy; SBRT = stereotactic body radiation therapy; Tx = treatment; Tx’d = treated; USC = universal survival model.