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. Author manuscript; available in PMC: 2017 Nov 11.
Published in final edited form as: N Engl J Med. 2017 May 11;376(19):1835–1848. doi: 10.1056/NEJMoa1614814

Figure 1. An Example of Deeply Infiltrative Endometriosis in the Colon.

Figure 1

In Panel A, a segment of involved colon shows a papillary lesion projecting into the lumen. Panel B shows the cross section of the colonic wall that is indicated by the rectangle in Panel A; arrows indicate endometriotic lesions. In Panel C, a section stained with hematoxylin and eosin shows multiple, discrete endometriotic foci (arrows) infiltrating into the muscle layer of the colon. The box indicates the approximate region that is core-targeted for molecular analysis. In Panel D, a higher magnification shows the characteristic morphologic features of endometriosis, with both glandular and stromal components. Results for all 24 exome-sequenced patients are shown in Panel E; not all patients’ samples yielded detectable somatic mutations. Both “driver” and “passenger” mutations are indicated (Tables S1 and S2 in Supplementary Appendix 2). As opposed to driver mutations, passenger mutations are defined as somatic mutations that are not known or presumed to directly contribute to cancer initiation or progression.